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‘Wegovy could be key to curing heart failure’


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Novo Nordisk said its hugely popular drug Wegovy was shown to substantially ease heart failure in obese people, as the Danish drugmaker seeks to further build its case for the medicine’s health benefits beyond weight loss.

In a statement on Friday, the company said that after one year on Wegovy participants in the late-stage study lost weight and had a 16.6-point improvement on a 100-point health scale based on a range of heart failure-related criteria.

People in a parallel group without the treatment in the trial, known as STEP HFpEF, saw a 8.7 point improvement, resulting in an estimated net benefit from Wegovy of 7.8 points.

The trial with 529 volunteers focused on a heart condition known as ‘preserved ejection fraction’, or HFpEF, where heart muscles stiffen and draw in less blood, mainly affecting overweight people.

The drug was shown to be “able to ease the disease burden for people with HFpEF and obesity in a substantial way,” said Martin Lange, head of development at Novo.

Novo this month raised the prospect of additional health benefits from taking Wegovy, apart from losing weight and cutting the risk of heart disease, as shown in a larger separate trial known as SELECT.

The Danish drugmaker also earlier this month published better-than-expected headline results from that study, saying the weekly injection cut the risk of heart attacks and strokes by 20 per cent.

HFpEF accounts for about half of heart failure cases, with symptoms including shortness of breath and swelling of extremities.

The company said in a presentation in June that the drug had “demonstrated superiority” in that trial.

It said on Friday it would discuss the trial with regulators, who could potentially approve a wider use.

Showing specific medical benefits is crucial for Novo’s push to move Wegovy beyond its image as a lifestyle drug.

Novo’s latest research was also presented on Friday (August 25) at the European Society of Cardiology (ESC) Congress in Amsterdam and published in the New England Journal of Medicine.


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