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DHSC issues supply notification for five different contraceptives

The Department of Health and Social Care (DHSC) has issued a medicine supply disruption notification for oral contraceptive tablets of various brands.

The following oral contraceptive preparations are currently out of stock.


Product affectedIngredientsAnticipated Resupply DateManagement Advice
BrevinorEthinylestradiol/norethisterone 35microgram/500 microgram tabletsLate October 2020No exact equivalent available
NoriminEthinylestradiol/norethisterone 35microgram/1mg tabletsNovember 2020No exact equivalent available
SynphaseEthinylestradiol/norethisterone/ 35microgram/500microgram and

35microgram/1mg tablets

November 2020Unlicensed imports of Synphase tablets have been sourced; lead times vary.
YiznellEthinylestradiol/drospirenone 30microgram/3mg tabletsTBCEquivalent alternatives with same composition remain available from suppliers of following brands: Dretine, Yacella, Yasmin, Ellaite and Lucette.
ZoelyEstradiol/nomegestrol 1.5mg/2.5mg tabletsSeptember 2020No exact equivalent available

The importers, Clinigen, Mawdsleys, and Target Healthcare have confirmed that they can source unlicensed Synphase tablets.

“There is currently no listing on dm+d for the imported product for prescribers to select using their prescribing systems so an EPS prescription for unlicensed Synphase tablets cannot be issued,” the DHSC has said.

If a prescriber wishes to prescribe an unlicensed import, an FP10 paper prescription should be issued as ‘Ethinylestradiol/norethisterone/35microgram/500microgram  or 35microgram/1mg tablets (special order)‘ and endorsed by the pharmacy as a non-Part VIIIB special.