The latest phase of the vaccination programme will see the over-75s, older care home residents and individuals aged 12 years and over who are immunosuppressed being invited for their boosters.
The spring dose is advised around 6 months after the last vaccine dose to maintain high levels of immunity for those deemed the most vulnerable.
Children aged 5 to 11 years will also begin being offered their first vaccination from today. Parents and guardians will need to consent to them having the vaccine.
Health boards across Wales have been planning for the latest stage of the vaccination programme for a number of months.
All those eligible for spring boosters are being encouraged to wait for their invitations from their health board or GP. It comes after Health Minister Eluned Morgan accepted the JCVI advice to give another boost to people who are at higher risk of severe COVID-19.
Health boards are also offering children aged 5 to 11 their first vaccination appointments. This is a precautionary offer to increase their immunity against severe COVID-19 in advance of a potential future wave and to minimise disruption to their education.
Most 5 to 11 year old children will be offered 2 doses of the vaccine, 12 weeks apart.
Health Minister Eluned Morgan said: “It is important we maintain high levels of protection from COVID-19 and everyone who is offered a spring booster vaccination takes up the invitation. We are following the latest advice from the JCVI and would everyone who is eligible to wait for the offer of their spring booster.”