GlaxoSmithKline (GSK) says initial tests of the antibody-based Covid-19 therapy it is developing with US partner Vir suggest the drug is effective against the Omicron variant.
A GSK statement on Thursday (December 2) said that lab tests and a study on hamsters have demonstrated the sotrovimab antibody cocktail to work against viruses that were bio-engineered to carry a number of hallmark mutations of the new variant.
The tests are continuing to confirm the results against all of the Omicron mutations, with an update expected by the end of the year, it added.
The antibody is designed to latch on to the spike protein on the surface of the coronavirus, but Omicron has been found to have an unusually high amount of mutations on that protein.
“Sotrovimab was deliberately designed with a mutating virus in mind," said Vir chief executive George Scangos, adding that the drug was targeting a region of the spike protein that was highly unlikely to mutate.
Separately, the Medicines and Healthcare products Regulatory Agency (MHRA) on Thursday approved sotrovimab, also known under the brand name Xevudy, for people with mild to moderate Covid-19 and who are at high risk of developing severe disease.
MHRA recommended use of Xevudy as soon as possible and within five days of the onset of symptoms.
Sotrovimab is based on monoclonal antibodies, which are lab-made versions of the natural antibodies the body generates to fight off an infection.
Similar products are offered or being developed by Eli Lilly, Regeneron and AstraZeneca.
Regeneron on Tuesday said that lab tests and computer modelling suggest that Covid-19 antibody drugs, including Regeneron's, would have reduced efficacy against the Omicron variant.
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