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Various strengths of Mirtazapine, Metronidazole, and Ketotifen face supply disruption

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The Department of Health and Social Care (DHSC) has issued a medicine supply notification for Mirtazapine 15mg and 45mg orodispersible tablets.

Mirtazapine 15mg orodispersible tablets are out of stock until late July, whereas Mirtazapine 45mg orodispersible tablets will face supply disruption until mid August.

Unlicensed orodispersible tablets are available to fulfill the needs of the patients.

Mirtazapine 30mg orodispersible tablets remain available, but cannot support an increased demand.

There will be sufficient supply of Mirtazapine 15mg, 30mg and 45mg tablets.

Metronidazole (Acea) 0.75 per cent Gel
A medicine supply disruption notice for Metronidazole (Acea) 0.75 per cent gel has been issued.

Acea 0.75 per cent gel will remain out of stock until September. However, Metrogel 0.75 per cent gel and Rozex 0.75 per cent gel remain available, DHSC has said.

ketotifen 1mg/5ml elixir
ketotifen 1mg/5ml elixir (Zaditen) is also facing supply disruption. Zaditen 1mg/5ml elixir is currently out of stock without a confirmed resupply date.

Zaditen 1mg tablets are available and can support demand of the elixir if deemed appropriate.

Alium Medical, Target Healthcare, and Waymade have confirmed that they can source unlicensed ketotifen 1mg/5ml elixir.

Earlier, Zaditen 1mg tablets and 1mg/5ml elixir were discontinued in 2019. However, this year both preparations were re-introduced back to the UK market.

There is currently no listing on dm+d for the imported product for prescribers to select using their prescribing systems so an EPS prescription for unlicensed ketotifen 1mg/5ml elixir  and mirtazapine orodispersible tablets cannot be issued.

If  a prescriber wishes to prescribe an unlicensed import, an FP10 paper prescription should be issued as ‘Ketotifen 1mg/5ml elixir (special order)‘ and endorsed by the pharmacy as a non-Part VIIIB special.

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